ABSTRACT

          The study on anaemia in pregnancy is aimed at determining packed cell volume (PCV), Haemoglobin (Hb) level and Erythrocyte sedimentation rate (ESR) of pregnant women, as well as the selferity, significance of maternal, age, educational level, occupation and gestational age to the occurrence of anaemia in pregnancy managed, diagnosed and admitted at the university of Nigeria teaching Hospital (UNTH) Enugu.  The result showed that most of the patient had moderate to secure anaemia and that the cases were commonest in the age range 25-29 years.  Most of the patient were housewives and low level civil servants who lived in middle and lower class residential area ad who had no formal education.  Anaemia in pregnancy was seen to occur most commonly in the third trimester.  It occurred all through the year, but mostly in the wet season and had the greatest positive association with malaria and nutritional deficiency.  Anaemia in pregnancy was seen not to be rampant in our today’s society due to the small number that tested positive Anaemia in pregnancy was also seen not to have any effect on birth weight of babies.

TABLE OF CONTENTS

Cover page

Title page

Certification

Dedication

Acknowledgement

Abstract

CHAPTER ONE

INTRODUCTION

Epidemology

Classification

Types of Anaemia

Pathophysiology

Aims and Objectives

Statement of Problems

Limitations/Scope

CHAPTER TWO

LITERATURE REVIEW

Hereditary Spherocytosis

Glucose – 6 – Phosphate

Ineffective Condition

CHAPTER THREE

MATERIALS AND METHOD

Collection of Samples

Sterilization

Determination of Packed cell volume

Determination of Haemoglobin (Hb)

Determination of Erythrocyte

Sedimentation rate (ESR)

Determining the significance of age, Educational level, etc

Method of Data collection

Method of data Analysis

CHAPTER FOUR

RESULTS

Distribution of pregnant women

Distribution of patients according to their occupation

Distribution of patients according to their educational level

Distribution of patients according to severity.

CHAPTER FIVE

DISCUSSION

Distribution

Distribution pregnant women by age

Percentage of  Anaemia in pregnancy etc.

CHAPTER SIX

CONCLUSION / RECOMMENDATIONS

Action by the Government etc.

References

Appendix

CHAPTER ONE

INTRODUCTION

DEFINITION:  The world health organisation (WHO) index for anaemia in pregnance is when the haemoglobin level in the peripheral blood is Hg/dl or less. However, from practical experience in tropical obstetrics it is generally accepted that anaemia in pregnancy Exist when the Haemoglobin level is less than in loglde or the packed cell volume less than 30%

EPIDEMOOGY:

          Anaemia in pregnancy presents a world-wide problem but it is uncommon in developed world.  the importance of anaemia in pregnancy in the tropics lies firstly in its greatly increased incidence, and secondly in the seventy of the anaemia with which the patients commonly present for treatment.  Both combine to make this complication of pregnancy a major cause of matanal and fetal death in the tropics.  A third important problem  posed by anaemia in the tropics is polymorphism.  In almost all cales, the anaemia is caused by multiple factors whole individual importance varies from area to area.  This makes rational prophylaxis and treatment much more difficult.  Complicaion of pregnancy in the for at belt of West Africa, between January and April 1955.  it was directly responsible for more than 20% of all matanal deaths in patients under the car of the Department of obstetrics, university college Hospital, Ibadan.  It also contributed to many other deaths from Antepartum haemorrhage, postpartum haemorrhage and puerperal sepsis.  In Nigeria it is a frequent complication, its incidence is high and its severity is staggering.  The clinical feathers of anaemia in pregnancy in Nigeira are different from those encountered in temperate countries not only because of the severity of symptoms but also because of the concomitant autuminosis such as marked glossitis, Angular stomatitis and associated gross hepatomegly.  Agbola A. (1991)

CLASSIFICATION

          Anaemia in pregnancy could be mild, moderate or severe based on the haemoglobin level in the peripheral blood as well as the clinical manifestations and the management would differ for each.

TYPES OF ANAEMIA                   HB LEVEL

Mild Anaemia in pregnancy    9-Hg/dl

Moderate Anaemia in pregnancy 7-9g/dl

Severe Anaemia in pregnancy 7g/dl

PATHOPHYSIOLOGY

For haemoglobin and Red blood cell synthesis, iron, folate, vitamin Biz and Vitamin c, trace elements like cobate and copper, and proteins are required. Erythroporetin produced by the renal parenchyma stimulates the bone marrow to increase erthropesis which is one of the noticeable physiological changes in pregnancy.  Barnes, F.C (1994).

In the non-pregnant female, the total body is about 3.5-kg. 2/3 of this is Haemoglobin another ¼ is in the body stores and the remaining is in the tissue and plasma.  Iron is stored in the liver and spleen as femitin and in bone marrows haemosiderin.  Iron in the serum is bound to transfer in, a B1 – globulin and transfers is only 1/3 saturated with iron.  A good diet provides about 10-15mg of iron per a day and only 10% of this is absorbed.  Iron is mainly absorbed in the duedenuim and to some extent in the upper jejunum.  The absorption is influenced by dietary phosphates, phytaces, ascorbic acid, sugars especially frutole, Hell in the stomach and gastric factors namely factors I, II and II, iron is lost in the bile, urine, fences, sweat and during menstruation.  About 1-2mg of iron is lost daily.

In normal pregnancy, iron demand is increased many folds.  The fetus need about 350mg, the placenta about 100mg:  the increased material haemoglobin mass about 350mg and that from lactation about 150mg.  In adding the pregnant women still excretes iron but on the credit side about 225mg of iron is available as a result of the amenorrhea of pregnancy is about 15%.  The increased iron requirement is not uniformly spread over the  period of pregnancy but as pregnancy advances from 28 weeks onwards,  the increased demand is noticed as a resultant drop in PCV or HB concentration it no iron supplementation has been given Abidu, O, Sofola (1990).

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