Download Category: PHARMACEUTICAL SCIENCE PROJECT TOPICS


PHARMACOECONOMIC ANALYSIS OF HIV AIDS MANAGEMENT PHARMACY

ABSTRACT The HIV/AIDS pandemic has resulted in mortality surge and life expectancy drop throughout the world. Developing countries are mostly affected due to their limited health care system and resources to handle the increasing costs of management of HIV/AIDS and associated opportunistic infections. The objective of this study is to estimate direct and indirect costs of managing HIV/AIDS to both the health sector and the patients, at Murtala Muhammad Specialist ...

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CURRENCY SUBSTITUTION AND THE DEMAND FOR MONEY IN NIGERIA: 1980 – 2014

ABSTRACT The persistent increase in demand for foreign currency, especially in recent years, exerts pressure on Nigeria's foreign exchange market. This trend is often accentuated by economic agents’ perceived loss of purchasing power and confidence in the domestic currency. Therefore, resort to holding currencies that have a relatively stable value such as the United States dollar (USD) which in turn increases the extent of currency substitution in the economy. This ...

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AN ECONOMIC ANALYSIS OF QUALITY OF LIFE AND LIVING CONDITIONS IN ZARIA LOCAL GOVERNMENT AREA OF KADUNA STATE

ABSTRACT Recent measures of welfare tend to go beyond the conventional focus on resources to a wide range of other aspects due to the multidimensional nature of quality of life. Such an approach is however limited by lack of clear framework for evaluating quality of life particularly at the micro level. This study evaluates the quality of life, living conditions and the effectiveness of governance in Zaria Local Government Area ...

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TOXICOLOGICAL ASSESSMENT OF THE METHANOL LEAF EXTRACT OF SECURINEGA VIROSA(ROXB EX. WILLD) IN WISTAR RATS

ABSTRACT     Securinega virosa is one of the African medicinal plants described as a true ‚Äúcure all‚ÄĚ among traditional practitioners. Different parts of Securinega virosa have been used in the management of different disorders in Nigeria and other parts of the world. There is therefore the need to establish the toxicity profile of Securinega virosa leaves. In this study, toxicological assessment of the methanol leaf extract of Securinega virosa ...

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THE ROLES OF PHARMACISTS IN CARE OPTIMIZATION FOR SCHIZOPHRENIC PATIENTS IN FEDERAL NEURO-PSYCHIATRIC HOSPITAL MAIDUGURI, NORTH-EASTERN NIGERIA

ABSTRACT   Provision of pharmaceutical care to patients suffering from schizophrenia posses special challenges due to complexity of the disease state, stigmatization and the side effects associated with antipsychotics. The aim of this study was to evaluate the roles of pharmacists in care optimization for schizophrenic patients. The perception of schizophrenic patients to the roles of pharmacists in care optimization was evaluated under 3 domains: managing therapy, interpersonal relationship and ...

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SPECTROPHOTOMETRIC DETERMINATION AND STABILITY STUDIES OF ARTEMETHER IN ARTEMETHER-LUMEFANTRINE SUSPENSIONS MARKETTED IN NIGERIA

ABSTRACT   The increasing use of artemether-lumefantrine combination as an effective treatment for resistant malaria demands the need for analytical methods for the quality control of these drugs in tablets and suspensions. Though some UV Spectrophotometric methods have been developed for quantification of artemether in various biological fluids and formulations, they require strainous heating conditions which is a limitation. This limitation coupled with non-availability of HPLC hence the need to ...

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TOXICITY AND IMMUNOMODULATORY PROPERTIES OF METHANOL EXTRACT OF THE STEM BARK OF LANNEA ACIDA A. RICH. (ANACARDIACEAE) IN WISTAR RATS

ABSTRACT     Lannea acidaA. Rich.belongs to the family of Anacardiaceae; and the bark, leaves and roots have been reported to possess many medicinal properties, including immunomodulatory activity.Despite this widespread belief, data on the immunomodulatory properties and safety of this plant is still lacking. The aim of this work was to determine the toxicity and immunomodulatory properties of the stem bark of Lannea acida in Wistar rats. Methanol extract of ...

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SOLID DISPERSION AS AN APPROACH FOR SOLUBILITY AND DISSOLUTION ENHANCEMENT OF IBUPROFEN AND PIROXICAM

ABSTRACT   The aim of this study was to enhance the solubility and hence dissolution rate of two poorly   soluble¬†¬†¬†¬†¬†¬†¬†¬† drugs:¬†¬†¬†¬†¬†¬†¬† ibuprofen¬†¬†¬†¬†¬†¬†¬†¬† and¬†¬†¬†¬†¬†¬†¬† piroxicam¬†¬†¬†¬†¬†¬†¬†¬† using¬†¬†¬†¬†¬†¬†¬†¬† Eudragit¬†¬†¬†¬†¬†¬†¬† RS¬†¬†¬†¬†¬†¬†¬† 100¬†¬†¬†¬†¬†¬†¬†¬† and   hydroxymethylpropylcellulose (HPMC) as carriers, by solid dispersion technique and to evaluate the effect of trona (sodium sesquicarbonate) on the dispersions . Solid dispersions of ibuprofen and piroxicam were prepared using HPMC or Eudragit RS 100 and their combinations by ...

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SYNTHESIS AND ANTICONVULSANT STUDIES OF 3 ISOMERS OF 4-[(DIMETHYLPHENYL)AMINO]-4-OXOBUTENOIC ACID

CHAPTER ONE 1.0 INTRODUCTION 1.1         Background Epilepsy is a chronic disorder of the brain that affects people in every country of the world. It is characterized by recurrent seizures from episodic discharge. Seizures are brief episodes of involuntary shaking which may involve a part of the body (partial) or the entire body (generalized) and sometimes accompanied by loss of consciousness and control of bowel or bladder function. (WHO, 2016) Brain ...

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THE EFFECT OF VITAMIN C ON PHARMACOKINETIC PARAMETERS OF CHLOROQUINE IN HEALTHY HUMAN VOLUNTEERS

ABSTRACT     This study was undertaken to compare the effect of vitamin C on the pharmacokinetics of chloroquine using human volunteers. Quality control studies for both chloroquine and vitamin C; identification test, assay, weight variation, friability, disintegration time and dissolution rate were carried out according to BP 2009. Jayanathi et al., 1994 method was adopted and validated based on ICH guideline for this study. Calibration curve was constructed within ...

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PHYTOCHEMICAL AND ANTIMICROBIAL STUDIES OF Spermacoce verticillata (Rubiaceae) G.F.W. Meyer

ABSTRACT The plant Spermacoce verticillata is used in ethnomedicine for the treatment of itches, diarrhoea, sores and other ailments. The hexane soluble fraction of acetone extract of the whole plant Spermacoce verticillata was subjected to phytochemical and antimicrobial screening. The phytochemical techniques employed were dry column vacuum chromatography and preparative thin layer chromatography. The antimicrobial activity was studied using agar diffusion, and broth dilution methods. The result of preliminary phytochemical ...

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PHYTOCHEMICAL AND ANTIMICROBIAL STUDIES ON THE STEM-BARK OF COMMIPHORA MOLLIS (Oliv. ) Engl. (BURSERACAEA)

ABSTRACT   Commiphora mollis is traditionally used in the treatment of fever (malaria and typhoid) wound healing, cancer, ulcer and rheumatic condition. The plant grows in Nigeria and across Africa. Phytochemical analysis of methanol extract of the stem-bark of Commiphora mollis showed the presence of flavonoids, saponins, tannins, terpenoids and alkaloids. Extensive Phytochemical studies of ethylacetate water soluble fraction of methanol extract resulted in   isolation (55 fractions, 100ml each ...

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PHYTOCHEMICAL AND INHIBITION STUDIES OF GARCINIA KOLA HECKEL (GUTTIFERAE) SEED EXTRACTS ON SOME KEY ENZYMES INVOLVED WITH DIABETES

ABSTRACT Garcinia kola is an Angiosperm belonging to the family Guttiferae. It is known in commerce as bitter kola. The plant seeds have been used in the treatment of a wide range of diseases including diabetes, and its importance in folkloric medicine as a purgative, mastcatory, aphrodisiac etc. is eminent. Diabetes mellitus is a metabolic disorder of multiple etiologies characterized by chronic hyperglycemia leading to severe complications such as neuropathy, ...

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PHYTOCHEMICAL AND ANTICONVULSANT STUDIES OF METHANOL LEAF EXTRACT OF HYMENOCARDIA ACIDA, TUL (EUPHORBIACEAE)

ABSTRACT     The research was on the phytochemical and anticonvulsant studies of methanol leafextract of Hymenocardia acida, Tul, (Euphorbiaceae) used inNorthern Nigeria for the treatment of headache, rheumatic pain, sickle cell crisis, malaria, epilepsy and cancer. The preliminary phytochemical screening of crude methanol extract (CME) using standard methods revealed the presence of terpenoids, tannins, saponins, alkaloids and flavonoids.Phytochemical evaluations were carried out using silica gel column chromatography, preparative thin ...

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PHARMACOLOGICAL INTERACTION BETWEEN ETHANOL EXTRACT OF MORINGA OLEIFERA LEAVES AND METFORMIN IN ALLOXAN-INDUCED HYPERGLYCAEMIC WISTAR RATS

Abstract   Herbs with anti-diabetic activity could initiate interactions if used concurrently with orthodox drugs. Moringa oleifera is one of such herbs usually taken as an adjunct to orthodox oral hypoglycaemic agents. This study investigated the possible pharmacological interaction between the ethanol extract of Moringa oleifera leaves (MOE) and metformin co-administered to hyperglycaemic Wistar rats and the effect of MOE on normoglycaemic rats. Hyperglycaemia was induced by administration of a ...

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PHYSICOCHEMICAL AND RHEOLOGICAL MODELING OF SYNERGISTIC INTERACTION OF SOME PLANT GUM EXUDATES.

ABSTRACT The visco-elastic properties of Khayasenegalensis (KS gum), Anacardium occidentale (AO gum) and Acacia senegal (AS gum) blends in dilute solution were investigated. The gums were evaluated for intrinsic viscosity and the elastic component. Molecular conformation of the complex of AS-KS was assessed by the power law and the results showed that the b values for AS 40%‚ÄēKS 60% and AS 20%‚Äē KS 80% given as 1.98 and 1.67 which ...

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FORMULATION STUDIES OF TABLETS CONTAINING ADANSONIA DIGITATA L. MUCILAGE AS MATRIX FORMER

ABSTRACT The aim of this study was to investigate the ability of Adansonia digitata mucilage (ADM), a hydrophilic plant polymeric material to prolong the release of Metoprolol tartarate (MPT) from matrix tablet formulations compared with semi -synthetic polymer-HPMC60SH4000 matrices. Phytochemical screening and physicochemical characterization of the extracted ADM was performed using standard and official procedures. Physicochemical tests such as simple (quantitative yield, aqueous solubility and pH tests) and analytical techniques ...

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PHARMACOGNOSTIC AND ANTIULCER STUDIES ON THE LEAF OF LEUCAS MARTINICENSIS (JACQ) R.Br. (LAMIACEAE)

ABSTRACT   Leucas martinicensis is an annual herb which is used for repellant of mosquito. It has minty odor. It is an erect plant which is usually unbranched, with length of up to 1m, which is finely hairy. The plant are widely used in Northern part of Nigeria and it has been exploited for both its medicinal and economic properties with no scientific justification about its antiulcer activities. It is ...

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IMPACT OF PHARMACIST’S INTERVENTION ON PATIENTS’ KNOWLEDGE AND ATTITUDE TOWARDS THEIR DIABETES MANAGEMENT IN A TERTIARY HOSPITAL IN NIGERIA

ABSTRACT Diabetes mellitus (DM) is the most common endocrine disorder. It is a chronic metabolic condition characterized by hyperglycaemia due to impaired insulin secretion with or without insulin resistance.Most diabetic patients have inappropriate knowledge of the clinical disorder and  thus  unaware  of  the  health  implications  of  non-adherence.  This  study  was  aimed  at assessing knowledge and attitude of diabetics to the management of their clinical disorder and also further examined the ...

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HYPOTENSIVE ACTIVITY AND TOXICOLOGICAL PROFILE OF STEM BARK EXTRACT OF SYZYGIUM GUINEENSE (Willd, D.C. Myrtaceae) IN LABORATORY ANIMALS

ABSTRACT Hypertension of unknown cause is called essential or primary hypertension while hypertension of a known cause is called secondary hypertension. Hypertension is called a silent killer because it is usually asymptomatic. It is a global problem affecting 1 in 3 adults in the United States. It is preventable and treatable disease. Orthodox drugs for its management are expensive and have associated side effects. Alternative source with good efficacy and ...

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