MOLECULAR PROFILING AND PHYLOGENETIC ANALYSIS OF THE ERG11 GENE OF FLUCONAZOLE RESISTANT STRAINS OF CANDIDA SPECIES ISOLATED FROM HUMANS AND DOGS OF REPRODUCTIVE AGE
ABSTRACT The clinical resistance of Candida species to antifungal medications, particularly fluconazole, is rising. A major mechanism responsible for this resistance is the alteration in the nucleotide sequence of the gene that codes for the ERG11 protein, a key enzyme in the ergosterol synthesis pathway, which remains the target of fluconazole. This study investigated the distribution of different species of Candida in human and dog vaginal swabs, the susceptibility of ...
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