Download Tag: WISTAR RATS

ABSTRACT This study investigated the effect of cocoa polyphenol on isoproterenol-induced myocardial infarction in Wistar rats. Polyphenol was extracted from cocoa using a hydroalcohol solvent. Forty albino rats divided into six groups of four rats each were used for the study. Groups 3, 4, 5 and 6 were pretreated with the extract (300, 500 and 700 mg/kg) and 100 mg/kg of atenolol (standard drug) respectively before administration with isoproterenol. Group ...

ABSTRACT     Securinega virosa is one of the African medicinal plants described as a true “cure all” among traditional practitioners. Different parts of Securinega virosa have been used in the management of different disorders in Nigeria and other parts of the world. There is therefore the need to establish the toxicity profile of Securinega virosa leaves. In this study, toxicological assessment of the methanol leaf extract of Securinega virosa ...

ABSTRACT     Lannea acidaA. Rich.belongs to the family of Anacardiaceae; and the bark, leaves and roots have been reported to possess many medicinal properties, including immunomodulatory activity.Despite this widespread belief, data on the immunomodulatory properties and safety of this plant is still lacking. The aim of this work was to determine the toxicity and immunomodulatory properties of the stem bark of Lannea acida in Wistar rats. Methanol extract of ...

ABSTRACT   The efficacy and toxicity of several drugs is circadian-rhythm dependent, and this can be exploited as a guide to ameliorate such drug toxicity. Gentamicin is an aminoglycoside antibiotic used in treatment of a variety of infections. Its use is however limited by its associated nephrotoxicity. This nephrotoxicity is ameliorated by reduction in dosing frequency to once a day dosing, use of antioxidants and exploration of circadian variation in ...

CHAPTER ONE 1.0  INTRODUCTION 1.1 Background Lead is a heavy, low melting, bluish-gray metal that occurs naturally in the Earth's crust. However, it is rarely found naturally as a metal. It is usually found combined with two or more other elements to form lead compounds. For these reasons, lead has been used by humans for millennia and is widespread today in products as diverse as pipes, storage batteries, pigments and ...