CHRONOMODULATED NIFEDIPINE ADMINISTRATION AND MICROVASCULAR COMPLICATIONS IN GLIMEPIRIDE-TREATED HYPERGLYCAEMIC RATS
ABSTRACT Diabetic complications pose increasing public health problems worldwide. Glimepiride, a sulphonylurea is among the most frequently used anti-diabetic drugs, and is often combined with other drugs for the management of type 2 diabetes mellitus. Nifedipine, a calcium channel blocker is recommended for its role in mitigating microvascular complications especially in delaying the onset of diabetic nephropathy. Interaction between both drugs leads to regimen failure when simultaneously administered. However, ...
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