CHITIN AS A POSSIBLE ADJUVANT FOR RECOMBINANT HEPATITIS B VACCINE IN MICE
ABSTRACT Although adjuvants are a common component of many vaccines, there are few adjuvants licensed for use in humans due to concerns about their toxic effects. The currently available HBV vaccines contain hepatitis B virus surface antigen (HBsAg) as the immunodominant antigen and alum as an adjuvant. Alum, the most commonly used adjuvant in vaccines licensed for human use, predominantly activates Th2-type humoral immune responses, but is poorly effective in ...
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